Janssen vaccine pros and cons: single dose but similar side effects to AstraZeneca

The US approved on Saturday the authorization of (Johnson & Johnson). And it is expected that on March 11 the European Medicines Agency will also do so. Both the US and Europe are looking forward to the arrival of this vaccine because it will be a shock to the rate of immunization of the population.

The Ministry of Health has reported that this fourth vaccine will foreseeably be approved this March, but that vials will not arrive in our country until A delay that according to the ministry was already contemplated in the contracts with the pharmaceutical company.

In addition, the US company clarified at the end of February that it will not supply 200 million doses of its vaccine to the European Union in the second quarter of 2021, as it had announced on Friday, but will do so throughout the year. Thus, the ministry expects that in the second quarter of the year some 80 million doses will reach Europe, of which Spain would correspond to just over 10%, that is, 8 million doses.

Janssen vaccine pros: single dose and easy logistics

Johnson & Johnson’s vaccine will be a major boost in vaccination efforts in the US and Europe. This is for two main reasons:

1. This vaccine only needs one dose to be effective, while those of Moderna, Pfizer or AstraZeneca need two injections administered at a certain time.

2. This vaccine is easier to store as it is stable for two years at -20 degrees Celsius, and for at least three months in most standard refrigerators at temperatures between 2.2 and 7.7 degrees Celsius. It should be remembered that the Moderna and Pfizer vaccines need a maintenance temperature of -20 degrees (for Pfizer before it was -80 degrees). And outside of these temperatures, the Pfizer vaccine lasts 5 days in a refrigerator, while the Moderna resists up to 30 days.

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Cons of the Janssen Vaccine: Side Effects and Effectiveness

1. Tests with the Janssen vaccine have shown an effectiveness against the coronavirus of 66%, a figure similar to the effectiveness of the AstraZeneca vaccine (with the two doses applied), but far from the levels of Pfizer or Moderna, which They are around 94-95%. However, the company has ensured that it has an 86% capacity to avoid severe cases of the disease, hospitalizations and deaths and that it is effective against all variants. Thus, experts have highlighted that it is still good.

2. Side effects: the Johnson & Johnson vaccine, unlike those of Moderna and AstraZeneca that are based on the messenger RNA molecule, is made up of an adenovirus that contains the genetic material (DNA) necessary for the cells of the body to begin to produce the S protein, which serves as an antibody against SARS-CoV-2. A system that also follows the AstraZeneca vaccine and that is also registering side effects in younger people.

He explains that some of the most common side effects of the Janssen vaccine are headache and fatigue. In addition, other symptoms such as muscle pain, nausea or fever were recorded. And, also, redness and swelling in the injection area.

This document has also revealed that 26.4% of people between 18 and 59 years of age and 9.8% of the group over 60 years of age needed treatment with analgesics after receiving the vaccine. The truth is, here the Ministry of Health already recommends treatment with Paracetamol before and after the AstraZeneca vaccine.

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